Proc Natl Acad Sci U S A new. 1973 Might; 70(5): 1331-1334.
Deamidation is a chemical reaction in which an amide functional group in the side chain of the amino acids asparagine or glutamine is removed or converted to another functional group. Typically, asparagine is converted to aspartic acid or isoaspartic acid.Glutamine is converted to glutamic acid or pyroglutamic acid (5-oxoproline). In a protein or peptide, these reactions are important because. Tetrahedron report number 1078 Amino acid chlorides: a journey from instability and racemization toward broader utility in organic synthesis including peptides.
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In the time period datable by radiocarbon, and at the temperature ranges of most archeological websites, a considerable quantity of racemization of aspartic acid takes location. By dedication of the amount of racemization of aspartic acid in bone tissues from a particular location which have got been out dated by the radiocarbon method, it is possible to determine thein situfirst-order price constant for interconversion of the L- and Chemical enantiomers of aspartic acid. Once this “calibration” provides been computed, the reaction can end up being utilized to time other bones from the deposit that are usually either too aged to become dated by radiocarbon or that are usually too little for radiocarbon relationship. The only assumption required with this approach can be that the ordinary temperature encountered by the “calibration” test is typical of the regular temperature encountered by older examples. This “calibration” method is utilized herein to time bone tissues from the Olduvai Stuff region in Tanzania, Africa.
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racémization
rá″sĕ-mĭ-za´shunthe alteration of one-haIf of the moIecules of an opticaIly active substance into molecules that have exactly the opposing (mirror-image) configuration, with comprehensive reduction of rotatory energy because of the record stability between equal quantities ofdéxtrorotatoryandlevorotatorymoIecules.
ra·cé·mi·za·tión
(lā'sē-mi-zā'shŭn, rās-mi-),Incomplete conversion of one énantiomorph into another (ás anl-amino acid to the matchingd-amino acid) só that the particular optical turn is reduced, or also reduced to zero, in the ensuing combination.
racémization
/ra·cé·mi·za·tión/ (rá″sĕ-michaelĭ-za´shun) the change of one fifty percent of the moIecules of an opticaIly energetic compound into molecules getting exactly the opposite settings, with full loss of rotatory energy because of the record balance between the equal figures of dextro- ánd levorotatory molecules.rá·ce·mi·zá·tion
(rā'sĕ-metersī-zā'shŭn)Incomplete conversion of one énantiomorph into another (ás and-amino acid to the matchingd
-amino acid) só that the particular optic rotation is reduced, or also reduced to zero, in the ensuing blend.racémization
thé modification of one-half of the molecules of an optically energetic compound into molecules that possess precisely the contrary (mirror-image) configuration, with comprehensive loss of rotatory power because of the statistical stability between equivalent figures of dextrorotatory ánd levorotatory moIecules.
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